Similar to PNI, cancer–nerve crosstalk in the context of neuritogenesis and neoneurogenesis not only occurs through direct communication (i.e., cancer-induced neuritogenesis via the release of NGF [70,71]), but also takes place indirectly via the neural regulation of other cells within the TME (e.g., immune and endothelial cells) [11,69,72] (Figure 1b). This evidence concerns the gene NGF and cancer.