LEP and Glucose intolerance: They demonstrated that male AdipoR1KOs have greater adiposity and glucose intolerance, resulting in weight gain and energy expenditure, increased liver triglyceride (TG) and plasma leptin (a satiety hormone produced and secreted by white adipose tissue (WAT) [32]) levels, in addition to higher AdipoR2 mRNA expression in brown adipose tissue (BAT), a thermogenic tissue.