PARP1 and Alzheimer disease: We generated a transgenic line expressing both Aβ42 peptide and short inverted repeat interfering PARP-1 (HMC04658), under the control of the pan-neuronal driver elav-Gal4; the transgenic strain elav-Gal4 > Aβ42; PARP-1RNAi (HMC04658) allowed us to analyze the climbing activity of AD flies in a genetic background depleted of PARP-1.