To verify whether PARP-1 inhibition could have relevant systemic effects in rescuing reduced lifespan of elav-Gal4 > APP, BACE1 flies, we performed lifespan experiments by feeding AD (elav-Gal4 > APP, BACE1) and control (elav-Gal4/+) flies on a standard cornmeal-sucrose-yeast-agar medium supplemented with 25 μM olaparib or 50 μM MC2050 over the entire developmental period. The gene discussed is BACE1; the disease is Alzheimer disease.