EGFR and central nervous system cancer: Several hypotheses can be proposed to explain the role of 5-HT7R on the development of gliomas: (i) 5-HT7R is known to be coupled to Gs/cAMP pathways, we suggest that changes in cAMP levels may participate in the switch of metabolic state and cell differentiation; (ii) 5-HT7R may also acts by modifying metabolism, as we observed metabolic alterations induced by 5-HT7R; and (iii) 5-HT7R can interfere with EGFR signalling.