Specifically, two peptides of Aβ42 (APP695 region 597–638, peptide 6–16 and peptide 17–28) and tau phosphopeptides (pS191, pT217, pT231, pS262, pS262/T263, and pS289) showed significant increases in asymptomatic AD and AD groups compared with control samples [31]. The gene discussed is MAPT; the disease is Alzheimer disease.