DES and neoplasm: Several growth factors secreted by tumor cells, such as PDGF-B, VEGF-A, and TGFβ-1, may trigger the prevalence of a PDGFRβ+/desmin+ pericyte phenotype through the acquisition of αSMA, RGS5, NG2, and desmin immunopositivity in activated pericytes at BCBM sites [32].