NFE2L2 and cancer: Mild or moderate stress can evoke normal physiological functions of cells due to adoptive increased resistance of Nrf2-mediated antioxidant response [1,4], while excessive stress evokes adverse signaling and that may, in turn, lead to age-related disorders, including neurodegenerative disorder, cancer, diabetes, acute respiratory distress syndrome, hypertension, obesity, ocular disorders such as cataractogenesis, glaucoma, etc. [5,6,7,8,9,10].