SMYD2 and cancer: In the context of a project aimed to study the role of SMYD2 in cancer [36], SMYD2-sufficient and SMYD2-deficient HT-29 cells (Figure 1A), a human colorectal cancer cell line that has been widely used for many years, were implanted into Rag1−/− mice via subcutaneous injection, and RNA-seq analysis of HT-29 xenografts was performed (Figure 1B).