Co-cultures of astrocytes and midbrain dopamine neurons from type 1 and type 2 GD patients revealed reduced GCase activity and GlcCer and GlcSph accumulation, which were accompanied by increased alpha-synuclein aggregates when treated with extracellular alpha-synuclein monomers and fibrils, as well as inflammation [38]. The gene discussed is SNCA; the disease is Gaucher disease type II.