In addition, electrophysiological data revealed impairment of two cellular correlates of learning and memory, long-term potentiation and long-term depression in a Nr2f1 HET mouse model [11], suggesting that altered synaptic plasticity may also contribute to BBSOAS intellectual impairment. The gene discussed is NR2F1; the disease is Bosch-Boonstra-Schaaf optic atrophy syndrome.