NR2F1 and Periventricular heterotopia: However, it must be noted that large deletions and complex chromosomal aberrations can involve additional genes located next to the NR2F1 locus, such as FAM172A, POU5F2, MIR2277 and lnc-NR2F1, adding to the complexity of the condition, and possibly leading to supplementary congenital abnormalities, such as periventricular heterotopia and deafness, among others [27,28,29].