NR2F1 and Bosch-Boonstra-Schaaf optic atrophy syndrome: An example of complex comorbidity in a BBSOAS-like context comes from an Nr2f1-haploinsufficient mouse model recapitulating visual syndromic features, which showed concomitant RGC decreased survival, oligodendrocyte hypomyelination and astrocyte inflammation in the ON of developing mutants [16,41].