Whereas the plasma of our PC participants was enriched in fibrinogen as previously reported [51,66], increased plasma inter-alpha-trypsin inhibitors ITIH2 and ITIH3 distinguished our GH and PE from PC participants, and plasma fibronectin may be a distinct driver of the heightened procoagulation in preeclampsia (Figure 1C). This evidence concerns the gene ITIH2 and preeclampsia.