In addition, ZA promotes a marked reduction in the LXR target genes Abcg1, Mertk, Scd1 and Srebp-1c in the tumor microenvironment and potentiated the antitumor effects of active and adoptive immunotherapy, significantly prolonging the overall survival of tumor-bearing mice treated with the combo ZA and TAA-loaded dendritic cells [144]. The gene discussed is SCD; the disease is neoplasm.