The inclusion of the IL6R rs2228145 polymorphism, as well as the alleles HLA-B*27 and HLA-DRB1*04, associated with a risk of RA development in the studied population [13,14], allows to increase the AUC to 0.6831 (p = 0.0009). The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.