Our results show that CA genotype and the C allele were associated with increased susceptibility to T2DM (Table 5) which is probably due to reduced GLO1 enzyme activity (as a result of structural perturbation) that leads to the accumulation of its cytotoxic substrate MG, hereby causing insulin resistance and T2DM [44,45]. The gene discussed is GLO1; the disease is type 2 diabetes mellitus.