While determining the allelic comparisons, the C allele of glyoxalase I gene polymorphism is strongly associated with increased susceptibility to T2DM disease with OR = 2.24(95%) CI (1.519–3.326), RR = 1.43(1.184–1.740), p < 0.0001). The gene discussed is GLO1; the disease is type 2 diabetes mellitus.