Our results indicate that in the codominant model, the CA genotype of the glyoxalase I gene is associated with increased susceptibility to T2DM with OR 2.57 (95%) CI = (1.4821 to 4.4835), RR = 1.43 (1.15–1.76), p < 0.0008 (Table 5). This evidence concerns the gene GLO1 and type 2 diabetes mellitus.