IDH1 and glioma: Considering the anti-tumor and immunosuppressive functions of this type of macrophage in gliomas, this observation could be in keeping with a less suppressive and less tumor-supportive inflammatory microenvironment in NT-1 gliomas, partly explained by their IDH status but also promoted by operational neurotransmitter signaling pathways modulated by released GABA or glutamate in cancer or microenvironment cells [61].