Similar to the TCGA cohort, the NT-2-like cluster was mainly composed of IDH-wt gliomas (222/259 or 85.71%) whereas IDH-mutated gliomas were predominant in the NT-3- and NT-4-like clusters (122/166, 73.49% and 226/275, 82.18% for the NT-3- and NT-4-like clusters, respectively; Supplementary Data Table S8). This evidence concerns the gene IDH1 and central nervous system cancer.