When specifically examining IDH-wt gliomas ascribed to NT-1-4 clusters, we found a higher proportion of IDH-wt gliomas bearing an EGFR amplification observed when comparing NT-2 vs. NT-1 gliomas but not NT-4 (49.44%, 23.81% and 40.54% for NT-1, NT-2 and NT-4, respectively; p = 1.88 × 10−2 and p = 0.25). Here, IDH1 is linked to central nervous system cancer.