Wagener-Ryczek et al. [23] showed an increase in CD3 expression in EC treated by up-front surgery by a factor of three in comparison to normal tissue, but there was a decrease in CD3 expression in patients treated by surgery after neoadjuvant chemotherapy in comparison to upfront surgery but still higher by twofold than normal tissue expression; however, CD8+ T cell was higher three folds in tumor tissue regardless of surgery first or after neoadjuvant chemotherapy. Here, CD8A is linked to neoplasm.