Anti-programmed death-1 (anti-PD-1) and programmed anti-death ligand 1 (anti-PD-L1) monoclonal antibodies (mAb) for patients with multiple cancers are licensed treatments, including nivolumab and pem-brolizumab for melanoma and non-small-cell lung cancer (NSCLC), nivolumab for renal cell carcinoma and Hodgkin’s lymphoma, atezolizumab for bladder cancer, and nivolumab plus ipilimumab for melanoma [94,95,96,97,98,99,100,101,102,103]. Here, CD274 is linked to melanoma.