Moreover, the substrate (Angiotensin I) and the product (Angiotensin 1,7) of the ACE2 enzyme is reported to be at an imbalance in other forms of acute respiratory distress syndrome [29], while low levels of Angiotensin 1,7 have been reported to be associated with the development of severe COVID-19 [30]. The gene discussed is ACE2; the disease is acute respiratory distress syndrome.