One-year hs-cTnT ≥ 39.4 pg/mL and NT-proBNP levels > 300 pg/mL, along with other factors such as male sex, eGFR < 60 mL/min/1.73 m2, and chronic obstructive pulmonary disease, were identified as independent predictors of long-term mortality in TAVR patients [93]. This evidence concerns the gene NPPB and chronic obstructive pulmonary disease.