IL4 and asthma: The better known inflammatory endotype in asthma, is that called type 2 (T2), because of the main role of type 2 T-helper cell (Th2)-which drive inflammatory responses (interleukin (IL)-4-, IL-5- and IL-13-mediated) [2,3,4], associated to other cells and cytokines such as type 2 Innate Lymphoid Cells (ILC2), IL-33, IL-25 and Thymic stromal lymphopoietin (TSLP) [5,6].