In GEPIA, the majority of the examined tumors exhibited enhanced COL4A1 expression, and its expression was significantly upregulated, especially in 12 tumor types, including diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), glioblastoma multiforme (GBM), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), low-grade glioma (LGG), liver hepatocellular carcinoma (LIHC), pancreatic adenocarcinoma (PAAD), skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD), testicular germ cell tumors (TGCT), and thymoma (THYM) (Figure 1a). The gene discussed is COL4A1; the disease is head and neck squamous cell carcinoma.