After adjustment for BMI, only four CpG sites (cg19693031 at TXNIP, cg06500161 at ABCG1, cg21234053 at CFL2, and cg14956201 at TRIO) remained genome-wide significant, indicating that obesity explained much of the association between DNA methylation and incident T2D. The gene discussed is ABCG1; the disease is type 2 diabetes mellitus.