Hierarchical clustering analysis for 1685 HCCs shows that ALP (>82 IU/L) is associated with the elevation of aspartate aminotransferase (AST; >43 U/L), alanine aminotransferase (ALT; >42 U/L), and the bilirubin level and the presence of cirrhosis, whereas the tumor status is associated with vascular invasion, satellite lesions, and a lack of tumor encapsulation [2]. Here, ALPP is linked to neoplasm.