Even though the dysregulated function of FGFR1, FGFR2 and FOXO1 has been examined in non-syndromic orofacial clefts, there has been limited research regarding the comparison of these factors in one individual’s two separate locations—cleft-affected lip tissue and cleft-affected palatine tissue. The gene discussed is FGFR2; the disease is orofacial cleft.