A multi-stage GWAS study in children with childhood AD and asthma found new genetic loci (rs9357733 positioned in EFHC1 on chromosome 6p12.3 and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3) that were specific for AD-asthma march phenotype [45]. Here, TMTC2 is linked to Alzheimer disease.