LEV (25 mg/kg; for six weeks) also showed neuroprotective effects in the neuropathy derived from diabetes; in mice, the regulation of the expression of apoptotic markers Tp53 and iNOS (tumor protein 53 and inducible nitric oxide synthase, respectively), as well as some neuronal indicators of stress and microglial activation, such as GFAP was decreased. This evidence concerns the gene TP53 and diabetes mellitus.