In addition, it has been shown that LEV (18 and 180 μM) significantly decreases the gene expression of excitatory amino acid transporter 2, (EAAT2) in brain metastasis glioblastoma cells culture, indicating that LEV has a mechanism of action that decreases the recapture of glutamate from the extracellular space in brain cancer [183]. The gene discussed is SLC1A2; the disease is glioblastoma.