Additionally, we carried out gene expression studies to identify alterations in key targets closely related to emotional reactivity and anxiety, such as Cnr1, Cnr2, Gpr55 and the α2 and γ2 subunits of GABA(A) receptors in the amygdala (AMY) and hippocampus (HIPP) of mice treated with CBD, and two brain corticolimbic regions involved in a broad range of behavioral and cognitive functions, including emotional regulation. The gene discussed is GPR55; the disease is Anxiety.