STAT3 and vascular dementia: In previous study, we analyzed the gene expression profiles of patients with AD and vascular dementia (VaD) in the Gene Expression Omnibus (GEO) database and found that the expressions of the Ras homolog gene family member A (RhoA), ICAM-1, angiotensinogen (AGT), phosphatidylinositol 3/kinase-protein kinase B (PI3K/AKT), and signal transducer and activator of transcription 3 (STAT3) were upregulated in both patient groups compared with healthy controls.