HPGDS and Marfan syndrome: In a prospective and observational study conducted with 17 patients with Marfan syndrome, Soto et al. [140] reported that daily supplementation with HS calyx infusion (20 g/L of boiling water) for 90 days significantly improved the activities of extracellular superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and total antioxidant capacity and ascorbic acid compared to patients with Marfan syndrome without supplementation.