Genes most strongly altered by each fumarate overlapped significantly with genes near loci implicated in MS by genetic association studies, although genes altered by IDMF overlapped more strongly with such genes (Figure 7), and our analysis identified several MS-associated genes uniquely altered by IDMF alone (e.g., down-regulation of TNFAIP3, CXCL8, IL6, and IRF1) (Figure 6). The gene discussed is IL6; the disease is myeloid sarcoma.