Toxic effects of astrocyte-generated IL-6 have also been supported by mouse models with transgenic over-expression of IL-6 in astrocytes, which exhibit a neurologically diseased phenotype characterized by tremors, ataxia, and seizures, with loss of neuronal subpopulations and increased reactive astrocytosis and neovascularization [78]. This evidence concerns the gene IL6 and cerebellar ataxia.