With the inflammatory stimulus of bacterial lipopolysaccharide (LPS), a potent TLR activator, VSMCs are activated and subsequently express proinflammatory mediators, such as inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, and IL-8, thereby contributing to VSMC injury and cardiovascular diseases [6,7]. This evidence concerns the gene NOS2 and cardiovascular disorder.