For leukopenia, there was no significant difference between patients with the ITPA 94C>A variant allele and wild-type homozygous patients (OR 1.75, 95% CI: 0.74–4.12; p = 0.20) using a random-effects model (I2 = 70%, p = 0.01) (Figure 2B). This evidence concerns the gene ITPA and Decreased total leukocyte count.