Notably, in contrast to AML cell cultures which displayed dramatic reductions in the live (annexin-V/PI-double negative) cell population in response to 2.5–10.0 μg/mL NUP or 0.05–0.25 μg/mL DTBN (e.g., Figure 2a and Figure 10c), no significant decrease in the percentage of live cells was observed in PBMC cultures treated with either agent for 24 h, as compared to control (Figure 12a,b). This evidence concerns the gene ANXA5 and acute myeloid leukemia.