The proapoptotic effects of different phytochemicals, such as the sesquiterpene lactone thapsigargin that is a specific inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase [38], and plant polyphenols [39,40,41,42] on cancer cells have been associated with the alteration of the intracellular Ca2+ homeostasis. Here, ATP2A3 is linked to cancer.