Cortisol levels were 1.8 μg/dL, 1.9 μg/dL, and 2.0 μg/dL (aim > 22 μg/dL) at 0, 30, and 60 min after ACTH (adrenocorticotropic hormone) administration, respectively, confirming the diagnosis of primary adrenocortical insufficiency. Here, POMC is linked to adrenocortical insufficiency.