IFNG and neoplasm: Both central-memory (Tcm) and effector-memory (Tem) T cells contribute to an anti-tumor response, where Tem rapidly acquire effector function, present with enhanced killing capacity and largely contribute to tumor-specific IFN-γ production [32]; Tcm in contrast reside in secondary lymphatic tissues due to their expression of CD62L and CCR7 and are characterized by a less pronounced effector status and a more stem-cell-phenotype with strong proliferative capacities, giving rise to Tem (and Teff) upon antigen restimulation [37,38].