Moreover, strong negative correlations were observed between levels of FoxP3−Helios− T cells with CD4+TIM-3+ T cells and CD4+LAG-3+ T cells in tumor tissues (r = −0.825, p < 0.0001; r = −0.672, p = 0.0006, respectively) but not in PBMCs and NILs (Figure 6B,C). Here, CD4 is linked to neoplasm.