CD4 and colorectal carcinoma: We have recently reported that some inhibitory ICs, including programmed cell death-1 (PD-1), cytotoxic T lymphocyte-associated antigen (CTLA-4), T cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), and lymphocyte-activation gene-3 (LAG-3) are upregulated on CD4+ T cells and play roles in CRC progression [7].