The most common gene mutations seen in CRC are adenomatous polyposis coli (APC), catenin beta 1 (CTNNB1), Kirsten Ras (KRAS), B-Raf (BRAF), small mothers against decapentaplegic homolog 4 (SMAD4), transforming growth factor beta receptor 2 (TGFBR2), tumor protein 53 (TP53), and phosphatidylinositol-4,5- bisphosphate 3-kinase catalytic subunit-alpha (PIK3CA) [6,7,8]. The gene discussed is CTNNB1; the disease is colorectal carcinoma.