Tanaka et al. (2008) [95] treated in vitro human HT29 female and HC116 male colon cancer cell lines with MPA at 20 nM for 48 h following transfecting the PR gene, and the results revealed potent antiproliferative effects and cell cycle arrest at the G0/G1 phase by decreasing the expression of cyclin E and increasing the expression of p21WAF1/CIP1 (Table 11). Here, PGR is linked to colonic neoplasm.