ESR2 and colonic neoplasm: Moreover, the authors found that ERβ transfection in the SW480 and SW620 cells increased the levels of miR-205 and suppressed the expression of PROX1 oncogene, which subsequently inhibited cell growth, arrested cell cycle at the G0 phase, and increased cell adhesion [109] Interestingly, ERβ re-expression along with high expression levels of miR-205 also reduced invasion and/or metastatic potential, particularly in SW620 metastatic colon cancer cells [109] (Table 6).