In addition, bioinformatics analysis allowed us to show that SNPs rs636933 and rs761142 of GCLC and rs2301022 of GCLM are significant eQTLs with loss-of-function effects of alternative alleles on gene expression in the brain, suggesting that an increase in brain infarct size might be the result of a decrease in the expression and/or activity of the genes that lead to a reduced synthesis of glutathione. This evidence concerns the gene GCLC and brain infarction.