For instance, allele T at SNP rs2301022 of GCLM protecting against ischemic stroke was associated with creating the binding sites for numerous transcription factors such as PDX1, ZSCAN26, ELF3, ZNF652, PAX4, SMARCC1, JDP2, FOXP3, ZBTB33, PRRX2, MEF2A, OTX2, DMBX1, RHOXF2, JUND, PITX1, JUNB, CUX1, HNF4A, UNCX, PAX5, FOSL2, HOXB5, BARX1, TFAP2A, SRF, VSX2, FOS, and POU6F2. The gene discussed is OTX2; the disease is ischemic stroke.