GPX3 and Stroke: Furthermore, in a previous study, we looked at the associations between polymorphisms in glutathione peroxidase genes such as GPX1 (rs1050450), GPX3 (rs2070593), and GPX4 (rs713041) and the risk of cerebral stroke in hypertensive patients, and we observed that SNP rs713041 of the GPX4 gene is associated with an increased risk of stroke [23].