RASEF and ischemic stroke: It is noteworthy that a strong protective effect of the rs2301022-T/T GCLM genotype on the risk of ischemic stroke was seen in the suppression of the negative effects of polymorphic genes such as rs4322086 of RASEF and rs12449964 of PEMT that have been found to be associated with an increased risk of ischemic stroke [55,56].