PD-1 and PD-L1 are being targeted on CAR-T clinical trials for lung cancer through αPD1-MSLN-CAR-T cells (NCT04489862), Zeushield Cytotoxic T Lymphocytes (NCT03060343), anti-CTLA-4/PD-1 expressing CAR-Ts (NCT03182816, NCT03182803), HerinCAR-PD1 cells (NCT02862028, NCT04429451), combination products (NCT03525782), or autologous aPD-L1 armored anti-CD22 CAR-T cells (NCT04556669). Here, MSLN is linked to lung carcinoma.