RNF213 and Moyamoya disease: A genome-wide association study (GWAS) analysis in Japanese patients with moyamoya disease demonstrated that 95% of familial patients and 46 out of 63 non-familial patients (73%) had the RNF213 p.Arg4810Lys variant, and this variant conferred a greatly increased risk of moyamoya disease (odds ratio, 190.8) [2].