RNF213 and Dilatation of the cerebral artery: Whole-exome sequencing of 233 French–Canadian patients with intracranial aneurysms identified 17 deleterious rare RNF213 variants, and the RNF213 single-nucleotide polymorphism rs6565666 was significantly associated with the occurrence of intracranial aneurysms in the French–Canadian population [15].