ACTA2 and Aortic dissection: A recent study of 702 Han Chinese patients with sporadic aortic dissection revealed that pathogenetic or likely pathogenetic RNF213 variants were identified in 26 patients (3.7%), and 7 of them did not have any pathogenetic variations in genes known to be associated with aortic dissection, such as FBN1, ACTA2, and MYH11.