Since atherosclerosis is an inflammatory reaction, factors such as matrix metalloproteinases (MMPs), the adhesion proteins intercellular adhesion molecule 1 (ICAM-1), and the vascular cell adhesion molecule 1 (VCAM-1) are associated with atherosclerotic plaque formation and thus, the instability of vulnerable plaques. The gene discussed is ICAM1; the disease is atherosclerosis.