Biomolecule composition of sEVs associated with inflammaging. CD14: monocyte differentiation antigen cluster of differentiation 14; IFITM3: interferon-induced transmembrane protein 3; NDUFS3: NADH dehydrogenase (ubiquinone) iron-sulfur protein 3, mitochondrial; CD63/9: tetraspanin-30/29; CAVN1: caveolae-associated protein 1; TGFBI: transforming growth factor-beta 1; FABP-4: fatty-acid-binding protein-4; TAU: aggregation-competent Tau; GSTM2: glutathione S-transferase Mu 2; NAMPT: nicotinamide phosphoribosyltransferase; AD: Alzheimer’s disease; T2D:type 2 diabetes. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.