In line with this hypothesis, Venanzi et al. [57] showed that the p62 DNA intramuscularly administered in various models of allogenic murine tumor (B16 melanoma, Lewis lung carcinoma (LLC), S37 sarcoma and Ca755 breast carcinoma) exerted a notable anti-tumor effect both in prevention and in a therapeutic setting. This evidence concerns the gene SQSTM1 and melanoma.