Upon endothelial damage, there is an increase in proinflammatory molecules such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP) leading to a proinflammatory endothelium and endothelial dysfunction. The gene discussed is IL6; the disease is endothelial dysfunction.