In a randomized, crossover, head-to-head study in 154 healthy women and men with abdominal obesity and low-grade systematic inflammation, supplementation with DHA compared with supplementation with EPA resulted in significantly greater reduction in IL-18 values (DHA versus control: −18.15 ± 6.25 pmol/L, EPA versus control: −2.12 ± 6.29 pmol/L, mean ± SEM, DHA versus EPA: p = 0.01), whereas changes in C-reactive protein, IL-6, and tumor necrosis factor-α (TNF-α) were not significantly different [98]. This evidence concerns the gene IL6 and Abdominal obesity.