Systematic review of five RCTs with altogether 949 participants showed that n-3 LCPUFA supplementation during pregnancy reduced 12-month prevalence of positive egg skin prick test (OR: 0.33; 95% CI: 0.16 to 0.70) and childhood asthma (OR: 0.35; 95% CI: 0.15 to 0.79), and significantly reduced cord blood IL-13 levels [103]. The gene discussed is IL13; the disease is childhood onset asthma.