N-3 LCPUFA (EPA and DHA) supplementation showed a clear reduction in medically diagnosed IgE mediated allergy in children aged 12 to 36 months (RR: 0.66; 95% CI: 0.44 to 0.98; 2 RCTs; 823 participants), but not beyond 36 months, or if allergy diagnoses on the basis of parental reports were included [104]. The gene discussed is IGHE; the disease is allergic disease.