Additionally, upregulation of miR-141 promotes the migratory and invasive abilities of an aggressive triple-negative breast cancer cell line MDA-MB-231 through regulation of the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) signaling pathway by increased secretion of vascular endothelial growth factor A (VEGF-A) and expression of integrin-αV [146]. Here, AKT1 is linked to triple-negative breast carcinoma.