YAP1 and cancer: Several studies have demonstrated that overexpression of miR-497 inhibited the proliferation, invasion, metastasis, angiogenesis or cell cycle of cancer cells, and induced apoptosis in HBC by targeting Bcl-2-like protein 2 (Bcl-w) [152], B-cell lymphoma 2 protein (Bcl-2) [153], yes-associated protein 1 (YAP1) [154], HIF-1α [155], or cyclin E1 [156] mRNA.