For example, B-Raf is targeted by dabrafenib and vemurafenib, MEK1/2—by trametinib (widely used in melanomas), CDK4—by abemaciclib, palbociclib and ribociclib in breast cancer, Bcr-Abl are targeted by dasatinib and imatinib in CML, erlotinib and gefitinib target EGFR in lung cancers (NSCLC). This evidence concerns the gene CDK4 and melanoma.