CYP2E1 and Parkinson disease: We recently demonstrated hypomethylation of the cytochrome P450 2E1 (CYP2E1) gene and increased expression of CYP2E1 mRNA in the brains of Parkinson’s disease (PD) patients in an independent study using the 27 K micro bead array in a more heterogeneous group of tissues, suggesting that epigenetic variants of this cytochrome (CPY) might contribute to PD susceptibility [5].