EUROLINE Systemic Sclerosis immunoblot has been approved for screening of 13 scleroderma-specific or associated antibodies: anti-Scl-70, CENPA, CENPB, RNAP-III (11 kDa), RNAP-III (155 kDa), fibrillarin (U3-RNP), NOR90, Th/To, PM/Scl-100. This evidence concerns the gene CENPB and scleroderma.