In a group of 287 SSc patients, Markusse et al. assessed the association between the degree of “scleroderma” type microangiopathy (“early”, “active”, or “late”) and extended autoantibody profile of SSc-related autoantibodies (anti-centromere, anti-Scl-70, anti-RNP, anti-RNAP III, anti-fibrillarin, anti-PM/Scl, anti-Th/To, and anti-Ku antibodies). The gene discussed is RNPC3; the disease is systemic sclerosis.