In the meta-analysis of these six studies including a total of 622 lesions [21,22,23,24,25,26], the pooled difference in proportions of type III curves (wash-out) between the high- and low-Ki-67 groups for all included tumours was 0.30, (95% CI = [0.17, 0.44]), heterogeneity τ2 = 0.02, I2 = 68%, test for overall effect Z = 4.42 (p < 0.01) (Figure 2c). Here, MKI67 is linked to neoplasm.